Drug Development (Prof. Pahnke): LIED

Drug Development of Neurodegenerative Diseases

Currently Funded Projects
BMBF / EU / JPND – PETABC: PET analyses of ABC transporter function for diagnosis and stratification of dementia patients (2021 – )

Further information about all ongoing research projects can be found at www.pahnkelab.eu/funding

Team members

Contact Details

Email: jens.pahnke(at)uksh.de
Web: www.pahnkelab.eu

Selected Publications

Farfara, D.; Sooliman, M.; Avrahami, L.; Grace, T.; Amram, S.; Rozenstein-Tsalkovich, L.; Trudler, D.; Blanga-Kanfi, S.; Eldar-Finkelman, H.; Pahnke, J.; Rosenmann, H.; Frenkel, D. Physiological Expression of Mutated TAU Impaired Astrocyte Activity and Exacerbates β-Amyloid Pathology in 5xFAD Mice
J. Neuroinflammation 2023, 20 (1), 174.

Möhle, L.; Stefan, K.; Bascuñana, P.; Brackhan, M.; Brüning, T.; Eiriz, I.; El Menuawy, A.; van Genderen, S.; Santos-Garcia, I.; Gorska, A. M.; Villa, M.; Wu, J.; Stefan, S. M.; Pahnke, J. ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer’s Disease. Biology 2023, 12 (7), 932.

Bascuñana, P.; Brackhan, M.; Möhle, L.; Wu, J.; Brüning, T.; Eiriz, I.; Jansone, B.; Pahnke, J. Time and Sex Dependent Effects of Fingolimod Treatment in a Mouse Model of Alzheimer’s Disease. Biomolecules 2023, 13 (2), 331.

Wu, J.; Möhle, L.; Brüning, T.; Eiriz, I.; Rafehi, M.; Stefan, K.; Stefan, S. M.; Pahnke, J. A Novel Huntington’s Disease Assessment Platform to Support Future Drug Discovery and Development. Int. J. Mol. Sci. 2022, 23 (23), 14763.

Brackhan, M.; Calza, G.; Lundgren, K.; Bascuñana, P.; Brüning, T.; Soliymani, R.; Kumar, R.; Abelein, A.; Baumann, M.; Lalowsk, M.; Pahnke, J. Isotope-labeled Amyloid-β does not Transmit to the Brain in a Prion-like Manner after Peripheral Administration. EMBO Rep. 2022, 23 (7), e54405.

Bascuñana, P.; Brackhan, M.; Pahnke, J. Machine Learning-supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia. J. Alzheimers Dis. 2021, 79 (2), 597–605.